diff --git a/Content.Shared/CombatMode/Pacification/PacificationSystem.cs b/Content.Shared/CombatMode/Pacification/PacificationSystem.cs
new file mode 100644
index 0000000000..d0cab6d096
--- /dev/null
+++ b/Content.Shared/CombatMode/Pacification/PacificationSystem.cs
@@ -0,0 +1,44 @@
+using Content.Shared.CombatMode;
+using Content.Shared.Actions;
+
+namespace Content.Shared.CombatMode.Pacification
+{
+    public sealed class PacificationSystem : EntitySystem
+    {
+        [Dependency] private readonly SharedActionsSystem _actionsSystem = default!;
+        public override void Initialize()
+        {
+            base.Initialize();
+            SubscribeLocalEvent<PacifiedComponent, ComponentInit>(OnInit);
+            SubscribeLocalEvent<PacifiedComponent, ComponentShutdown>(OnShutdown);
+        }
+
+        private void OnInit(EntityUid uid, PacifiedComponent component, ComponentInit args)
+        {
+            if (!TryComp<SharedCombatModeComponent>(uid, out var combatMode))
+                return;
+
+            if (combatMode.DisarmAction != null)
+            {
+                _actionsSystem.SetToggled(combatMode.DisarmAction, false);
+                _actionsSystem.SetEnabled(combatMode.DisarmAction, false);
+            }
+            if (combatMode.CombatToggleAction != null)
+            {
+                combatMode.IsInCombatMode = false;
+                _actionsSystem.SetEnabled(combatMode.CombatToggleAction, false);
+            }
+        }
+
+        private void OnShutdown(EntityUid uid, PacifiedComponent component, ComponentShutdown args)
+        {
+            if (!TryComp<SharedCombatModeComponent>(uid, out var combatMode))
+                return;
+
+            if (combatMode.DisarmAction != null)
+                _actionsSystem.SetEnabled(combatMode.DisarmAction, true);
+            if (combatMode.CombatToggleAction != null)
+                _actionsSystem.SetEnabled(combatMode.CombatToggleAction, true);
+        }
+    }
+}
diff --git a/Content.Shared/CombatMode/Pacification/PacifiedComponent.cs b/Content.Shared/CombatMode/Pacification/PacifiedComponent.cs
new file mode 100644
index 0000000000..c20e97bfd2
--- /dev/null
+++ b/Content.Shared/CombatMode/Pacification/PacifiedComponent.cs
@@ -0,0 +1,9 @@
+namespace Content.Shared.CombatMode.Pacification
+{
+    /// <summary>
+    /// Status effect that disables combat mode.
+    /// </summary>
+    [RegisterComponent]
+    public sealed class PacifiedComponent : Component
+    {}
+}
diff --git a/Resources/Locale/en-US/reagents/meta/toxins.ftl b/Resources/Locale/en-US/reagents/meta/toxins.ftl
index bbfc383874..1fea06f6b6 100644
--- a/Resources/Locale/en-US/reagents/meta/toxins.ftl
+++ b/Resources/Locale/en-US/reagents/meta/toxins.ftl
@@ -51,3 +51,6 @@ reagent-desc-uncooked-animal-proteins = This is very risky for the stomachs of s
 
 reagent-name-allicin = allicin
 reagent-desc-allicin = An organosulfur compound found in alliums like garlic, onions, and related plants.
+
+reagent-name-pax = pax
+reagent-desc-pax = A psychiatric drug which prevents the patient from directly harming anyone.
diff --git a/Resources/Prototypes/Entities/Mobs/NPCs/simplemob.yml b/Resources/Prototypes/Entities/Mobs/NPCs/simplemob.yml
index 9fe6ec4570..ab45ea29ef 100644
--- a/Resources/Prototypes/Entities/Mobs/NPCs/simplemob.yml
+++ b/Resources/Prototypes/Entities/Mobs/NPCs/simplemob.yml
@@ -110,6 +110,7 @@
     - Electrocution
     - ForcedSleep
     - TemporaryBlindness
+    - Pacified
   - type: Body
     template: AnimalTemplate
     preset: AnimalPreset
@@ -173,6 +174,7 @@
       - Electrocution
       - ForcedSleep
       - TemporaryBlindness
+      - Pacified
   - type: ThermalRegulator
     metabolismHeat: 800
     radiatedHeat: 100
diff --git a/Resources/Prototypes/Entities/Mobs/Species/base.yml b/Resources/Prototypes/Entities/Mobs/Species/base.yml
index 551ebd6151..862d8dfa98 100644
--- a/Resources/Prototypes/Entities/Mobs/Species/base.yml
+++ b/Resources/Prototypes/Entities/Mobs/Species/base.yml
@@ -81,6 +81,7 @@
       - Muted
       - ForcedSleep
       - TemporaryBlindness
+      - Pacified
   - type: DiseaseCarrier
   - type: Blindable
   # Other
diff --git a/Resources/Prototypes/Reagents/toxins.yml b/Resources/Prototypes/Reagents/toxins.yml
index f960c804fd..88be15117b 100644
--- a/Resources/Prototypes/Reagents/toxins.yml
+++ b/Resources/Prototypes/Reagents/toxins.yml
@@ -441,3 +441,18 @@
         damage:
           types:
             Poison: 6
+
+- type: reagent
+  id: Pax
+  name: reagent-name-pax
+  desc: reagent-desc-pax
+  physicalDesc: reagent-physical-desc-soothing
+  color: "#AAAAAA"
+  metabolisms:
+    Poison:
+      effects:
+      - !type:GenericStatusEffect
+        key: Pacified
+        component: Pacified
+        refresh: false
+        type: Add
diff --git a/Resources/Prototypes/Recipes/Reactions/chemicals.yml b/Resources/Prototypes/Recipes/Reactions/chemicals.yml
index 38e625d02c..f1c9369ad5 100644
--- a/Resources/Prototypes/Recipes/Reactions/chemicals.yml
+++ b/Resources/Prototypes/Recipes/Reactions/chemicals.yml
@@ -326,3 +326,16 @@
       amount: 1
   products:
     ChloralHydrate: 1
+
+- type: reaction
+  id: Pax
+  impact: Medium
+  reactants:
+    MindbreakerToxin:
+      amount: 1
+    Synaptizine:
+      amount: 1
+    Water:
+      amount: 1
+  products:
+    Pax: 3
diff --git a/Resources/Prototypes/status_effects.yml b/Resources/Prototypes/status_effects.yml
index 960f51ea23..b149243ed3 100644
--- a/Resources/Prototypes/status_effects.yml
+++ b/Resources/Prototypes/status_effects.yml
@@ -50,3 +50,6 @@
 
 - type: statusEffect
   id: TemporaryBlindness
+
+- type: statusEffect
+  id: Pacified #cannot attack